α-ketoglutarate (AKG/α-KG) is one of the intermediate products of the tricarboxylic acid cycle, and is a naturally occurring compound in the human body. It plays a key role in a series of reactions that release and store energy in the human body. Studies have shown that with age, the level of AKG in plasma will drop significantly. Moreover, α-ketoglutarate cannot be obtained from food and can be supplemented in the form of dietary supplements.
As a kind of dietary supplement, fitness enthusiasts take AKG to build muscle and shape. Since 2014, researchers have discovered the positive effects of AKG in prolonging healthy lifespan, as well as osteoporosis, chronic kidney disease, gastrointestinal diseases and other aspects. AKG has also been recognized by more people as “anti-aging”.
A paper published by the Buck Aging Institute team in September 2020 showed that supplementing with CaAKG (calcium salt form of AKG) can reduce the level of inflammatory cytokines in mice, so the mice can achieve 40% improvement in health indicators and 12% extension The average life span.
In terms of heart health, previous clinical studies have shown that the severity of heart failure in patients with acute or congestive heart failure (HF) is related to the level of plasma AKG in patients.
Recently, a research paper published on ScienceDirect Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice showed that the research team found through experimental studies that AKG can restore mitochondrial morphology and function, promote myocardial mitochondrial phagocytosis, and reduce ROS toxicity and cell apoptosis. Death.
In an experiment to study the effect of AKG supplements on the myocardial condition of HF mice, the team found that after AKG treatment, the pathological cardiac hypertrophy induced by TAC (transverse aortic constriction) can be reduced, and the hypertrophic cardiomyocytes of TAC mice The cross-sectional area was reduced by an average of 49.11%, and the mRNA and protein levels of cardiac hypertrophy markers were significantly reduced.
Effects of AKG Supplements on Myocardial Condition in HF Mice
AKG also has a certain relief effect on myocardial fibrosis symptoms
At the same time, the results of this study show that AKG can also relieve the symptoms of myocardial fibrosis to a certain extent. By inhibiting TGF-β1, the main protein of myocardial fibrosis, AKG treatment also achieved the effect of inhibiting myocardial fibrosis in mice. In addition, for ROS that can cause mitochondrial dysfunction, myocardial damage, and heart failure, after supplementing with AKG, the content of ROS in TAC mice was reduced by 50.81%, and at the same time, the apoptosis of mice was significantly reduced.
However, it should be noted that most of the current research results and claims about the benefits of AKG in regulating immune function, bone development, heart health, etc., are based on the role of AKG itself in the human body, but whether AKG is taken in the form of supplements There is no data to show that it can achieve the enhancement of the corresponding functions of the human body.