There are a lot of people with bad stomachs now, especially when it comes to stomach problems, and of course it is linked to chronic gastritis. In fact, you should know a lot about chronic gastritis.
What are the types of chronic gastritis?
Chronic gastritis refers to various inflammatory lesions of chronic gastric mucosa caused by different causes. According to the results of gastroscopic observation and pathological biopsy, chronic gastritis can be divided into chronic non-atrophic gastritis and chronic atrophic gastritis. Sometimes the patient’s stomach has erosion, bleeding, etc., can be directly seen by gastroscopy, so the gastritis is divided into erosive gastritis, bile reflux gastritis, hemorrhagic gastritis and other types.
Conscious symptoms of chronic gastritis
Common symptoms of chronic gastritis include upper abdominal pain, loss of appetite, postprandial fullness, acid reflux, and nausea. But not all patients have symptoms, and the severity of the symptoms is often inconsistent with the extent of gastric mucosal lesions. Therefore, the severity of the disease cannot be measured based on the severity of the self-perceived symptoms.
Chronic atrophic gastritis is a precancerous disease
Chronic atrophic gastritis has received widespread attention due to its relevance to gastric cancer. The term “atrophy” refers to the expansion of the inflammatory lesion to the lamina propria of the gastric mucosa, resulting in destruction of the gland and fibrosis of the lamina propria. The development of chronic atrophic gastritis into gastric cancer is a gradual process, namely atrophic gastritis → intestinal metaplasia → dysplasia (dysplasia) → carcinoma in situ. Therefore, chronic atrophic gastritis is clinically regarded as the most common precancerous disease in stomach diseases, and if it is accompanied by dysplasia, it is a precancerous lesion. The former refers to benign gastric diseases associated with gastric cancer, and the risk of developing gastric cancer; the latter refers to pathological changes that are more likely to be converted into cancerous tissues, mainly refers to dysplasia.
Gastric mucosal intestinal metaplasia (referred to as intestinal metaplasia) refers to long-term chronic inflammation that replaces the epithelium and glands of the gastric mucosa with goblet cells. The wider the distribution of intestinal metaplasia, the higher the risk of developing gastric cancer.
Diagnosis of chronic atrophic gastritis requires “three combinations”
To correctly diagnose chronic atrophic gastritis, gastroscopy, pathological examination and clinical manifestations should be combined, with pathological diagnosis as the main diagnosis basis.
How to conduct early screening for gastric cancer?
If you can predict the outcome of patients with chronic atrophic gastritis, screening for high-risk groups that may be cancerous, and then closely follow-up gastroscopy for high-risk groups will help early detection of gastric cancer.
The study found that serum pepsinogen (PG) I, pepsinogen II and gastrin-17 test can help determine whether there is gastric mucosal atrophy and its severity; if combined with Helicobacter pylori antibody detection, it will help Risk stratification management. The serum pepsinogen level reflects the functional status of the gastric mucosa. When the gastric mucosa shrinks, the serum pepsinogen level decreases, and the pepsinogen I level decreases more significantly.
Method of preventing cancer
1. Removal of precancerous lesions under gastroscope is an effective means of preventing gastric cancer. Compared with traditional surgery, endoscopic treatment is not only effective, but also has less trauma and less complications, so it is recommended as the first choice for intraepithelial neoplasia (including severe dysplasia and carcinoma in situ). It mainly includes endoscopic mucosal resection and endoscopic mucosal dissection.
2. Eradication of Helicobacter pylori eradication of Helicobacter pylori has a good preventive effect on carcinogenesis of mild chronic atrophic gastritis, and can also reduce the risk of gastric cancer.
3. Drug prevention Another study suggests that the application of allicin and multivitamins also have long-term preventive effects. Some patients with low folate levels in the body, appropriate amount of folic acid can improve the pathological tissue state of chronic atrophic gastritis, which can reduce the incidence of gastric cancer.