Zegerid (omeprazole/sodium bicarbonate) powder for oral suspension and capsules – Center for Food Safety and Applied Nutrition

Literature suggests that concomitant use of PPIs with Methotrexate (primarily at high dose; see Methotrexate prescribing information) may elevate and prolong serum levels of Methotrexate and/or its metabolite, possibly leading to Methotrexate …