Do you understand interferon

  Recently, a patient with hepatitis B came to the outpatient clinic for consultation: the doctor recommended that he be treated with Weilide combined with interferon. The hepatitis B surface antigen may turn negative, but after the first injection of interferon, he has been fatigued, short of breath and joint pain. What is interferon? What should I do if there is an adverse reaction?
  What is interferon?
  Interferon is a family of multifunctional cytokines with broad-spectrum antiviral, immunomodulatory, anti-angiogenesis, anti-tumor, and anti-proliferation effects. There are mainly three kinds of α, β, and γ. Among them, alpha-interferon is a broad-spectrum antiviral drug and immunomodulator. It induces the production of a variety of antiviral proteins by acting on the corresponding receptors on the surface of the virus-infected cells, and then exerts an antiviral effect. It can be used clinically for virality. Diseases, such as viral pneumonia, hepatitis B, hepatitis C, etc.
  For patients with chronic hepatitis B, the biggest advantage of interferon treatment is that there is a clear course of treatment. Once it is effective, the treatment can be stopped according to the scheduled course. In general, doctors often recommend interferon for adolescent patients with high aminotransferases and patients with low baseline hepatitis B surface antigen levels. For the elderly, interferon therapy is rarely recommended because of concerns that they cannot tolerate side effects.
  In addition, women in pregnancy cannot take interferon; decompensated liver cirrhosis is also a contraindication to interferon therapy; patients with severe mental illness, such as severe depression and mania, cannot also Application of interferon treatment; some patients with severe autoimmune diseases that are not well controlled can not use interferon for the time being.
  There are also some conditions that are relative contraindications to interferon, such as poorly controlled hypertension or diabetes patients, or the patients themselves have low white blood cells and platelets. These patients should be adjusted according to the situation before treatment.
  Adverse reactions and interferon treatment
  prior to interferon therapy, be sure to consider interferon-related adverse reactions.
  The most common adverse reaction of interferon is that after the first injection, many patients will experience high fever, headache, and muscle aches all over the body. Clinicians call it “flu-like symptoms”, like having a bad cold, but these symptoms are not a particularly big problem. Most patients can heal on their own without treatment. Only a few patients need intervention, such as applying some non-steroidal anti-inflammatory drugs to relieve symptoms; or injecting interferon before going to bed, which can reduce discomfort.
  Because of the possibility of fever, the patient should be given the first injection of interferon under the supervision of a doctor or nurse. In some patients, after 1-2 injections, the adverse reactions will gradually ease, but there will be slight muscle soreness.