What is the high blood platelet

  As an important part of human blood, platelets have multiple functions and are active molecules in blood coagulation, inflammation and immune system. However, if the number of platelets is too high, it will cause blood to coagulate, causing blood to stop flowing, and possibly causing thrombosis. What conditions can cause high platelets? How to prevent it? Get to know it together.
Slightly higher than normal, don’t worry

  The normal platelet content is 100~300×109/L, occasionally slightly higher than this value, does not indicate any problem. The number of normal platelets will fluctuate to a certain extent, and there will be different reactions depending on the time, season, and other conditions. For example, after a person exercises, the platelet content will rise in a short time, but after a period of rest, the platelet count will return to normal; there are also some women whose platelet content will rise when the menstrual period comes. This is a normal physiological response , No need to worry about it.
  In addition, in the process of waiting in line for blood draw, there is no food or water. If the waiting time is long and the blood is not diluted with water, it will be concentrated. At this time, the number of platelets tested will also be higher than the normal value. In this case, if other values, such as white blood cells, platelets, hemoglobin, red blood cells, etc., are not abnormal, it is recommended to observe them first and pay attention to regular review.
Thrombocytosis should be vigilant

  If the results of multiple examinations are maintained at a certain high level (>400×109/L) for a long time, it can be called thrombocytosis. At this time, it is necessary to consider whether there are other diseases in the body. Most patients with thrombocytosis have no obvious symptoms of discomfort. Some are only found during routine blood tests. Some patients have symptoms such as nose bleeding, bleeding gums, fatigue, dizziness, headache, paresthesia, or come because of blood clots. See a doctor.
  There are many reasons for the increase of platelet count. According to the different mechanisms, it can be divided into pseudothrombocythemia, secondary thrombocytosis, and clonal thrombocytosis.
  Pseudothrombocythemia: Pseudothrombocythemia refers to the failure of fully automated blood cell counters to distinguish platelet-like substances in the blood (such as cryoglobulin, red blood cell fragments, etc.) and count them as platelets, resulting in platelets in the blood routine report The count is high. In this case, a simple peripheral blood smear can be identified.
  Secondary thrombocytosis: This is the most common type, mostly due to infection, iron deficiency anemia, abnormal splenic function, malignant tumors, hemolysis and other pathological conditions, as well as induced by drug application.
  Clonal thrombocytosis: Clonal thrombocythemia is a bone marrow disease characterized by an increase in the number of megakaryocytes responsible for the production of platelets in the bone marrow. Common causes include chronic myelogenous leukemia, myelodysplastic syndrome, and myeloproliferative tumors.
  Patients with thrombocytosis have the dual risks of thrombosis and bleeding, especially in patients with primary thrombocythemia. About 20% to 40% of patients have symptoms of microvascular thrombosis, and 11% to 25% of patients have complications of macrovascular thrombosis. Mainly, followed by coronary arteries; and with age, the risk of thrombosis gradually increases.
Primary antiplatelet therapy

  It can be seen from the above that there are many causes of thrombocytosis, the mechanisms are different, the prognosis is also very different, and the focus of treatment is also different. It is generally recommended to control the platelet count to <600×109/liter, and the ideal target value is <400×109/liter. The risk of thrombosis in patients with secondary thrombocythemia is relatively low, the platelet count can return to normal after treatment for the primary disease, and clinical antiplatelet therapy is usually not required. The progression of essential thrombocythemia is slow, and a treatment plan can be formulated after a comprehensive evaluation by a hematologist. The main purpose of treatment is to prevent thrombosis and bleeding complications, and reduce the risk of the disease transforming into myelofibrosis or acute leukemia.   Age older than 60 years old, previous history of bleeding/thrombosis, platelets>1500×109/liter are three risk factors affecting thrombosis and prognosis, and antiplatelet aggregation should be taken with oral aspirin and related platelet-lowering treatments, such as hydroxyurea , Interferon first-line medication, and regular blood routine. In addition, patients should maintain a regular schedule, develop a healthy life rhythm, exercise moderately, quit smoking and alcohol, drink more water, and eat less high-fat, high-salt foods.