How does the virus invade the human body and cause illness

  From the Spanish pandemic of the last century to the 2003 SARS we are familiar with, and the new coronary pneumonia that everyone is paying close attention to, the human body is fighting the virus all the time. So, how exactly does the virus invade human cells to replicate and reproduce, and make people sick?
Break through layers of defense and enter the cell

  There are about 100 trillion cells in the human body, which together with some organs and tissues make up the human immune system. Among them, white blood cells are responsible for patrolling everywhere in the human body, and are known as “human body guards.” When a virus is detected, the white blood cells will destroy the virus. If the number of invading viruses is huge, the immune system will mobilize many white blood cells to participate in the battle. When the forces are evenly matched and the battle is stuck, the body will have inflammation. At this time, go to the hospital for a blood test, the white blood cell value will be high. Everyone’s white blood cell combat power is strong or weak, so even in the face of the same virus, some people will develop diseases, and some people will be safe.
  If the virus is not completely wiped out by white blood cells, the virus that has escaped the white blood cell hunt will quickly approach the host cell. The host cell is the cell through which the virus invades, replicates and reproduces, and is referred to as “cell” hereinafter.
  Of course, the cell will not be caught with it. It also has its own defense system, including peripheral defense and internal security. Its outer line of defense is the cell membrane, which discriminates the visitor, and only allows it to enter the cell when it is confirmed that the visitor is not in danger. Larger molecules such as sugar and nutrients such as proteins can only enter smoothly after being identified. Viruses are the enemy of invasion, of course they cannot be identified. However, cunning viruses can secretly disguise, which requires careful inspection of cell membranes. The ability of cell membrane inspection and identification is related to the human immune function: if the immune function is strong and the virus is camouflaged, it will send a signal to white blood cells to eat the virus; if the immune function is weak, the cell membrane will not recognize the virus and the virus will be mixed in cell.
Fuzzy pass, close to the nucleus

  After the virus enters the cell, it must break through the various defense systems inside the cell to reach the nucleus. The goal of the virus is to penetrate the nucleus. There are lysosomes inside the cells, which are responsible for capturing and digesting viruses that enter the cell; those viruses that escape by chance continue to charge toward the nucleus. But the virus does not know the way, only the dynein in the cell can approach the nucleus through a special channel. Dynein is responsible for transporting nutrients into the cell nucleus, and transmitting instructions issued by the deoxyribonucleic acid (DNA) that sits in the nucleus to direct the operation of the entire cell. Just like when entering the cell membrane, the virus uses deception to make the dynein mistakenly believe that the virus is a nutrient needed by the nucleus. There is a special protein on the way to the nucleus, which is equivalent to the imperial guards, who will strictly inspect the goods being transported to the nucleus. Once it was discovered that the dynein was transporting a virus, it immediately notified the lysosome to come and eat the virus. So far, the virus plan completely failed. However, if the Guards neglect to find the virus, the virus will easily “take down” the nucleus.
  There are nuclear holes on the protective membrane outside the nucleus. Around the nuclear holes are protein tentacles, which are responsible for pulling materials needed by DNA into the nucleus and disseminating DNA instructions. Dynein transports the virus to the nuclear pore to the protein tentacles, and the protein tentacles transport the virus from the nuclear pore to the nucleus. But the nuclear pore is very small, and the protein tentacles cannot send the virus into the nucleus. Dynein did not wait patiently and turned around while carrying the virus. The protein tentacles mistakenly believed that the dynein was sending DNA urgently needed materials and held the virus. During the pulling, the protein shell of the virus was torn apart. This is in the middle of the virus, the shell is broken, the virus is thin, and it is sent into the nucleus by the protein tentacles.
Dove occupying magpie’s nest, hijacking cell DNA

  The DNA of the cell finds that the virus has broken into the nucleus, and it sends out instructions for dynein to call the white blood cells to destroy the cell that was captured by the virus, and at the same time make the neighboring cells prepare to resist virus invasion. There is a military type of white blood cells called “macrophages”, which are responsible for eating the cells that have been captured by the virus together with the virus. At this time, the human immune system’s tactics are “prefer to kill one thousand by mistake, not to let one go.” To be on the safe side, macrophages will eat some healthy cells around them while eating cells that have been captured by the virus. The macrophages completely wiped out the virus and the patient healed on his own.
  If the macrophages have not received instructions from the cellular DNA, the virus has hijacked the cellular DNA at this time, and the cellular DNA issues instructions according to the virus’s requirements, allowing the entire cell to serve the virus replication and reproduction. When the virus multiplies so much that the cell can’t hold it, the virus sends the DNA of the cell to order the cell to collapse, the cell collapses, and the virus army surges out to attack one cell after another, and the person becomes sick.

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